TABLE II.
Adjuvant chemotherapy: use, completion rate, and toxicity
| Variable | Age group | p Valuea | ||||
|---|---|---|---|---|---|---|
|
|
|
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| Overall | <65 Years | 65–69 Years | ≥70 Years | 65–69 Years | ≥70 Years | |
| Patients (n) | 134 | 286 | 60 | 92 | — | — |
|
| ||||||
| Adjuvant CTx [n (%)] | 177 (62) | 109(81) | 41 (68) | 27 (29) | 0.063 | <0.001 |
|
| ||||||
| CTx regimen [n (%)] | ||||||
| Capecitabine | 79 (45) | 45 (41) | 24 (59) | 10 (37) | ||
| FUFA, 5FUb | 63 (36) | 38 (35) | 12 (29) | 13 (48) | ||
| XELOX | 11 (6) | 7 (6) | 3 (7) | 1 (4) | ||
| FOLFOX | 12 (7) | 10 (9) | 2 (5) | 0 (0) | ||
| Other | 17 (10) | 12 (11) | 1 (2) | 4 (15) | ||
|
| ||||||
| Completion [n (%)] | 116 (66) | 76 (70) | 26 (65) | 14 (52) | 0.089 | <0.001 |
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| Dose reduction [n (%)] | 71 (40) | 40 (38) | 14 (35) | 17 (68) | 0.390 | 0.062 |
|
| ||||||
| Delay [n (%)] | 58 (33) | 40 (38) | 11 (28) | 7 (28) | 0.112 | <0.001 |
|
| ||||||
| Regimen change [n (%)] | 10 (6) | 9 (8) | 0 (0) | 1 (4) | 0.059 | 0.051 |
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| ||||||
| Toxicity [n (%)] | 125 (71) | 74 (68) | 28 (70) | 23 (85) | 0.281 | <0.001 |
| Mucositis | 31 | 20 | 5 | 6 | ||
| Diarrhea | 39 | 20 | 11 | 8 | ||
| Anorexia | 27 | 13 | 6 | 8 | ||
| Nausea, vomiting, or both | 23 | 18 | 2 | 3 | ||
| Hand–foot | 31 | 17 | 12 | 2 | ||
| Fever | 13 | 7 | 3 | 3 | ||
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| ||||||
| Toxicity grade [n (%)] | ||||||
| 1 | 44 (35) | 33 (45) | 5 (18) | 6 (26) | ||
| 2 | 59 (47) | 29 (39) | 19 (68) | 11 (48) | 0.008 | 0.274 |
| ≥3 | 22 (18) | 12 (16) | 4 (14) | 6 (26) | 0.424 | 0.165 |
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| ||||||
| Hospitalization | 18 (10) | 11 (10) | 3 (7) | 4 (14) | 0.752 | 0.750 |
a
Comparing the older age group with the group less than 65 years of age. Significant values appear in boldface type.
CTx = chemotherapy; FUFA= 5-fluorouracil–folinic acid; 5FUb= 5-fluorouracil bolus; XELOX = capecitabine–oxaliplatin; FOLFOX= 5-fluorouracil–oxaliplatin.