TABLE IV.

Cox multivariate regression analysis

Variable	Comparator	For overall survival				For disease-free survival
		HR	95.0% CI		p Valuea	HR	95.0% CI		p Valuea
			Lower	Upper			Lower	Upper
Age	<65 Years				0.413				0.945
65–69 Years		1.412	0.619	3.221	0.412	1.099	0.493	2.453	0.817
≥70 Years		1.660	0.763	3.611	0.201	0.939	0.429	2.055	0.876
Sex
Female	Male	0.823	0.413	1.641	0.580	0.624	0.312	1.249	0.183
ECOG PS
1–2	0	1.781	1.026	3.094	0.040	1.654	0.967	2.829	0.066
T Stage
T3–4	T2	2.088	1.015	4.297	0.046	1.481	0.756	2.902	0.252
N Stage
N1–2	N0	1.229	0.745	2.028	0.420	2.124	1.304	3.459	0.002
Differentiation	Well differentiated				0.690				0.919
Unknown		0.544	0.157	1.889	0.338	0.747	0.246	2.266	0.606
Poorly differentiated		1.163	0.362	3.738	0.800	1.157	0.382	3.504	0.797
Moderately well differentiated		0.991	0.414	2.373	0.984	0.948	0.430	2.090	0.894
Neoadjuvant chemoradiation
Yes	No	0.752	0.359	1.574	0.449	0.381	0.191	0.761	0.006
Adjuvant chemotherapy
Yes	No	0.321	0.157	0.656	0.002	0.379	0.187	0.769	0.007

^aSignificant values shown in boldface type.