TABLE II.

Multivariate analysis of factors associated with the use of contralateral prophylactic mastectomy

Variable	Adjusted OR	95% CI	p Value
Age	0.94	0.86 to 1.03	0.18
Neoadjuvant CTx	1.05	0.43 to 2.59	0.92
Tumour size
≤20 mm	Reference
21–50 mm	0.62	0.34 to 1.13	0.12
>50 mm	0.78	0.35 to 1.74	0.54
Node-negative	2.46	1.31 to 4.62	0.005
ER-negative	2.57	1.20 to 5.53	0.02
PgR-negative	0.51	0.24 to 1.10	0.08
LVI-positive	0.70	0.37 to 1.35	0.29
Grade
I	Reference
II	1.42	0.36 to 5.60	0.62
III	1.85	0.47 to 7.22	0.38
Multicentricity	0.88	0.49 to 1.58	0.66
Multifocality	0.88	0.48 to 1.58	0.66
Adjuvant CTx	1.32	0.64 to 2.69	0.45
Adjuvant radiation	0.92	0.53 to 1.62	0.78
Re-excision surgery	2.70	1.51 to 4.71	0.0007

OR = odds ratio; CI = confidence interval; CTx = chemotherapy; ER = estrogen receptor; PgR = progesterone receptor; LVI = lymphovascular invasion.