Table 2.
Top 20 significant KEGG biological pathways affected by maternal lifetime stress, grouped by KEGG class.
| KEGG Class/Path ID | KEGG Pathway Name | n | DE | FDR |
|---|---|---|---|---|
| Cellular Processes | ||||
| hsa04530 | Tight junction | 162 | 9 | 2.11E-05 |
| hsa04144 | Endocytosis | 252 | 13 | 1.00E-06 |
| Environmental Information Processing | ||||
| hsa04151 | PI3K-Akt signaling pathway | 317 | 13 | 6.56E-06 |
| hsa04080 | Neuroactive ligand-receptor interaction | 257 | 11 | 5.67E-06 |
| Hsa04015 | Rap1 signaling pathway | 206 | 11 | 6.93E-06 |
| Human Diseases | ||||
| hsa05165 | Human papillomavirus infection | 302 | 11 | 0.0002 |
| hsa05200 | Pathways in cancer | 384 | 15 | 4.74E-06 |
| Metabolism | ||||
| hsa00310 | Lysine degradation | 56 | 9 | 3.04E-08 |
| hsa01100 | Metabolic pathways | 1190 | 20 | 6.41E-05 |
| Organismal Systems/Development | ||||
| hsa04914 | Progesterone-mediated oocyte maturation | 86 | 7 | 4.42E-05 |
Based on 616 significant probes (FDR = 0.20) using a background probe set based on the 365,193 probes used in association testing. Abbreviations: n, number of genes corresponding to the full set of probes used in our association test that belong to that pathway; DE, number of genes corresponding to our set of significant probes (FDR = 0.20) that belong to the KEGG pathway in question; FDR, false discovery rate using Benjamini-Hochberg correction.