TABLE 4.
FISHER EXACT TEST FOR ASSOCIATION BETWEEN CLINICAL FEATURES AND CLASS 2 GENE EXPRESSION PROFILE AMONG 207 SUSPICIOUS CHOROIDAL MELANOCYTIC TUMORS
| VARIABLE | Class 1 N (%) |
Class 2 N (%) |
P-VALUE |
|---|---|---|---|
| Age >60 years | No: 88 (42.5) Yes: 75 (36.2) |
No: 12 (5.7) Yes: 32 (15.5) |
.002 |
| Thickness >2.25 mm | No: 62 (30.0) Yes: 101 (49.0) |
No: 6 (3.0) Yes: 38 (18.3) |
.002 |
| Absence of fibrous metaplasia | No: 139 (68.1) Yes: 22 (10.8) |
No: 40 (19.6) Yes: 3 (1.5) |
.3 |
| Largest basal diameter >12 mm | No: 129(62.3) Yes: 34 (16.4) |
No: 33 (16.0) Yes: 11 (5.3) |
.5 |
| Visual symptoms | No: 69 (33.5) Yes: 93(45.2) |
No: 16 (7.8) Yes 28 (13.6) |
.5 |
| Presence of subretinal fluid | No: 39 (21.0) Yes: 103 (55.4) |
No: 10 (5.4) Yes: 34 (18.3) |
.7 |
| Absence of RPE atrophy | No: 126 (62.0) Yes: 34 (16.7) |
No: 33 (16.0) Yes: 10 (5.0) |
.8 |
| Absence of any chronic feature | No: 100 (48.5) Yes: 62 (30.1) |
No: 28 (13.6) Yes: 16 (7.7) |
.8 |
| Tumor margin <3 mm from disc | No: 74 (36.0) Yes: 88 (42.8) |
No: 20 (9.7) Yes: 24 (11.7) |
1.0 |
| Absence of drusen | No: 126 (61.5) Yes: 35 (17.1) |
No: 35 (17.1) Yes: 9 (4.4) |
1.0 |
| Female sex | No: 76 (36.7) Yes: 87 (42.0) |
No: 19 (9.2) Yes: 25 (12.1) |
1.0 |
| Presence of orange pigment | No: 66 (32.2) Yes: 95 (46.3) |
No: 18 (8.8) Yes: 26 (12.7) |
1.0 |
| Low acoustic internal reflectivity | No: 17 (20.2) Yes: 42 (50.0) |
No: 7 (8.3) Yes: 18 (21.4) |
1.0 |
| Documented tumor growth | No: 86 (41.5) Yes: 77 (37.2) |
No: 26 (12.6) Yes: 18 (8.7) |
0.5 |
RPE, retinal pigment epithelium. Chronic RPE features include fibrosis, drusen and atrophy. Percentages may not add to 100% due to rounding.