Fig. 8. LC693 is virulent in a mouse model of CDI.

Four groups of mice (n = 10) were challenged with 10⁶ spores of UK6, LC693, CD630, or R20291. Mice were monitored for one week for survival (a) and weight changes (b). Animal survival was analyzed by Kaplan–Meier survival analysis with a log-rank test of significance (ns not significant, p > 0.05). The mean relative weight of mice was analyzed for significance using a Student’s t-test. *p < 0.05 between the CD630 and LC693 groups at 1, 2 and 3 days post challenge; p < 0.05, between the CD693 and UK6 groups at 2, 3, 5, 6, and 7 days post challenge; p < 0.05 between the LC693 and R20291 groups at 2 and 3 days post challenge; and p > 0.05 between the UK6 and R20191 groups at all assayed time points