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. 2018 Oct 24;30:91–104. doi: 10.1016/j.ddtec.2018.10.002

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© 2018 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Fig. 6 — Site-directed enzyme-mediated bioconjugation methods utilise (a) β-1,4-galactosyltransferase (Y289L) (b) transglutaminase and (c) sortase A (SrtA) enzymes. These have been used to incorporate ⁸⁹Zr-labelled DFO chelator and ⁶⁴Cu-labelled chelators, CPTA (a 1,4,8,11-tetraazacyclotetradecane derivative) and MeCOSar (a 3,6,10,13,16,19-hexaazabicyclo[6.6.6]icosane derivative). Metal complex charges are excluded.