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. 2018 Nov 19;47(4):453–463.e3. doi: 10.1016/j.devcel.2018.10.025

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© 2018 The Authors. Published by Elsevier Inc.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Myosin Distribution in AS Cells Presenting Different Levels of Stretch or E-Cadherin

(A) Scaled average cells showing the distribution of myosin in the case of WT, WT stretched, Rab5 DN, Rab5 DN stretched, and E-cadherin downregulation and overexpression (Shg RNAi and Shg overexpression, respectively). Myosin preferentially localizes to junctions when cells are stretched or E-cadherin levels are low.

(B) Histograms, corresponding to the average cells shown in (A), depicting the ratio of junctional myosin to medial myosin. Medial is defined as being further than 3 pixels from the segmented junction. Overall, myosin preferentially localizes to junctions when cells are stretched and when E cadherin is downregulated. (N_WT = 116 cells on 10 embryos, N_Rab5DN = 131 cells on 10 embryos, N_ShgRNAi = 45 cells on 4 embryos, and N_Shg = 62 cells on 5 embryos).