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. 2018 Dec 6;9:2833. doi: 10.3389/fimmu.2018.02833

Figure 2.

Figure 2

AHR signaling pathway. AHR is a ligand-activated transcription factor the resides in the cytosol being held in conformation by chaperone proteins until bound by ligand. Once bound by ligand, AHR translocates to the nucleus, sheds its chaperone proteins, and binds ARNT. This complex then binds XREs on DNA and induces gene transcription of genes such as CYP1A1. AHR, aryl hydrocarbon receptor; ARNT, aryl hydrocarbon receptor nuclear translocator; XRE, xenobiotic response element; CYP, cytochrome P450.