Table 2.
oprD mutations in Pseudomonas aeruginosa isolates resistant to carbapenems.
| Isolate | oprD mutation | Resulting change in the protein |
|---|---|---|
| 3A IMI | c.604ins (IS256 family transposase ISPa1328) | Protein truncated |
| 110A IMI | c.840_854delGGGCGCGTATACCCTinsCGGC | Frameshift and premature stop codon; Predicted protein of 313 aa |
| 111A IMI | c.875 T > C | p.292P > L |
| 117A IMI | c.970delA | Frameshift and premature stop codon; Predicted protein of 344 aa |
| 121A IMI | c.1244G > A | Nonsense mutation and premature stop codon; Predicted protein of 414 aa |
| 131A IMI | c.154G > A; c.397A > C; | p.52D > N p.132K > Q |
Strain used for comparison: P. aeruginosa ATCC 27853 (GenBank Accession Number KF649209.1). Missense mutations with respect to the reference strain are indicated only in those isolates without truncating mutations.