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. 2018 Dec 6;9:2803. doi: 10.3389/fimmu.2018.02803

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Copyright © 2018 Charvet, Reynaud, Gourru-Lesimple, Perron, Marche and Horvat.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Activation of MSRV-Env expression requires protein kinase C activity. (A) Schematic representation of putative phosphorylation sites within CD46-Cyt1 and Cyt2 and candidate kinases and their inhibitors (PKC: Protein Kinases C; CK-2: Casein Kinase 2). (B,E,H) Transactivation controls. (C,D) Effect of bisindolylmaleimide 5 μM (BIM) on HHV-6A-induced MSRV-Env expression; (F,G,I,J) absence of the effect of, Apigenin 40 μM and Scr-inhibitor 5 μM on MSRV-Env expression. The expression of MSRV-Env was analyzed by immuofluorescence, using anti-MSRV Env mAb, followed by anti-mouse-Alexa 555 (red staining, arrowhead) and representative images from 3 independent experiments were presented. DAPI (blue staining) was used to visualize cell nuclei, bar = 50 μm.