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. 2018 Dec 6;12:914. doi: 10.3389/fnins.2018.00914

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Copyright © 2018 Pozner, Schray, Regensburger, Lie, Schlötzer-Schrehardt, Winkler, Turan and Winner.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Rescue of neurite outgrowth abnormalities of SPG11 patients by tideglusib treatment. (A) Representative image of non-treated (left) and tideglusib treated (right) SPG11 neurons transfected with pEF1-dTomato. Neurite tracings are shown in the inserts. (B) The total neuritic length is significantly decreased in SPG11 neurons and it is recovered following tideglusib treatment. (C) The average number of SPG11 neurites is significantly decreased and it is recovered following tideglusib treatment. (D) Sholl analysis confirms a significant increase in neurite number following tideglusib treatment. Quantifications in C, D represent pooled data of CTRLs (CTRL-1, CTRL-2) and SPG11 (SPG11-1, SPG11-2, SPG11-3) iPSC-derived-neurons. Scale bar = 100 μm. Data shown as means ± SEM. ^∗P ≤ 0.05.