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. Author manuscript; available in PMC: 2019 Jul 20.
Published in final edited form as: J Org Chem. 2018 Jul 6;83(14):7480–7490. doi: 10.1021/acs.joc.8b00946

Scheme 1. Substrate scope for Mb(H64V,V68A,H93S)[(Co(ppIX)]-catalyzed cyclopropanation of vinylarenes with EDA.a.

Scheme 1.

a Reaction conditions: 10 mM olefin, 20 mM EDA, E. coli whole cells expressing Mb variants (OD600 = 80) in 50 mM phosphate buffer (pH 7.2). b Based on GC conversion. c For trans-(1S,2S) product. d Using 5 mM olefin and 10 mM EDA. Enantiomeric excess not determined.