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USP5 induces the nuclear translocation of β-catenin. Overexpression of USP5 in A549 cells elevated the level of total β-catenin, nuclear β-catenin, cyclin D1 and c-Myc, and knockdown of USP5 in H1299 cells decreased the levels of total β-catenin, nuclear β-catenin, cyclin D1 and c-Myc.
