Figure 7.

Knockdown of USP5 impaired the tumorigenesis of NSCLC cells in vivo. H1299-shUSP5 and H1299-shNC cells were injected subcutaneously into the hind limbs of nude mice. A. After 5 weeks, the tumor nodules were removed and photographed. B. Average weight of tumors in nude mice. C, D. Immunohistochemical analysis of USP5, b-catenin, c-Myc, cyclin D1 and Ki-67 in tumor nodules and comparison of expression was shown below. (Data were presented with mean ± SD of three independent experiments, *P < 0.05, **P < 0.01).