Figure 4.

The role of exosomes derived from CTLs (CTL-EXO) and CAR-T cells (CAR-T-EXO) in anti-tumor immunity. The presence of TCR/CD3/CD8 on CTL-EXO enable CTL-EXO target antigen expressing tumor cells specificly, and cytotoxic compounds contained in CTL-EXO kill the target cells. CAR-T-EXO may possess antibody-derived single-chain variable fragment (scFv), which determines the targeting specificity of CAR-T cells, can recognize specific molecules on target cells (such as CD19 on B-cell neoplasms) and kill them by cytotoxic compounds release.