Figure 5.

Regulation of PIP expression. In ER-negative breast cancer, the expression of PIP is auto-regulated by the positive feedback loop between PIP and ERK, Akt/PkB signaling [81,107,108]. AR-androgen receptor, CREB1-cAMP responsive element binding protein 1, DHT-dihydrotestosterone, ErbB2-Her2, human epidermal growth factor receptor 2, ERK1/2-extracellular signal-regulated kinases 1 and 2, ILK1-integrin-linked kinase 1, Jak-Janus-activated kinases, MSK-mitogen- and stress-activated protein kinase, PIP-prolactin-induced protein, PKB/AKT-protein kinase B/serine/threonine kinase, PRLR-prolactin receptor, RSK-ribosomal S6 kinase, Runx2-runt-related transcription factor 2, STAT5-signal transducer.