Figure 1.

THZ2 inhibits the growth of gastric cancer cells in vitro. A. CDK7 mRNA expression was analyzed between normal tissue and tumor tissue in gastric cancer of TCGA data. *P < 0.05 and **P < 0.01 vs. corresponding control. B. The protein expression of CDK7 in human gastric cancer cells was examined by Western blot, and 14-3-3 was used as loading control. The representative results of three independent experiments were shown. C. Chemical structure of THZ2. D. The representative growth curves of cells treated with THZ2 are shown. E. Summary of IC₅₀ of THZ2 in the indicated human gastric cancer cells cells is shown. F. The correlation analysis of THZ2 IC₅₀ values and relative CDK7 protein levels in five human gastric cancer cells is shown.