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. 2018 Nov 15;10(11):3395–3412.

Figure 6.

Figure 6

ZEB1-AS1 inhibits cell cycle arrest and apoptosis in glioma cancer cells through inhibition of miR-200c/141 and activation of ZEB1. A. Flow cytometry was used to detect cell cycle distribution in treated U87 cells. B. The percentage of treated U87 cells in G0/G1, S and G2/M phase were quantified, respectively. C. Apoptosis was detected by PI staining in treated U87 cells. D. The percentage of apoptosis cells in each group was quantified. *P < 0.05, **P < 0.01, siZEB1-AS1 + ZEB1 versus siZEB1-AS1 + Vector; #P < 0.05, ##P < 0.01, miR-200s + ZEB1 versus miR-200s + Vector. siNC: siRNA negative control; siZEB1-AS1 + Vector: ZEB1-AS1 stably deleted cells transfected with vector; siZEB1-AS1 + ZEB1: ZEB1-AS1 stably deleted cells transfected with ZEB1; miR-200s + Vector: U87 cells transfected with the mixtures of miR-200c and miR-141; miR-200s + ZEB1: U87 cells transfected with miR-200s and ZEB1.