Table 1.
Demographic distribution of RRM2B and CypD in breast cancer patients
| RRM2B | CypD | |||||
|---|---|---|---|---|---|---|
|
| ||||||
| High (%*) | Low | p value† | High (%*) | Low | p value† | |
| Age | ||||||
| <50 | 38 (54.3) | 32 | 32 (50.5) | 32 | ||
| ≥50 | 59 (64.1) | 33 | 0.205 | 58 (65.5) | 26 | 0.019 |
| pT stage‡ | ||||||
| T0-T1 | 35 (72.9) | 13 | 24 (55.9) | 19 | ||
| T2-T4 | 57 (54.8) | 47 | 0.034 | 62 (63.9) | 35 | 0.364 |
| pN stage‡ | ||||||
| 0 | 47 (55.3) | 38 | 39 (50.0) | 39 | ||
| 1-2 | 40 (65.6) | 21 | 42 (77.8) | 12 | ||
| 3 | 10 (62.5) | 6 | 0.446 | 9 (56.3) | 7 | 0.004 |
| Grade | ||||||
| 1 = Well | 12 (60.0) | 8 | 10 (55.6) | 8 | ||
| 2 = Mod | 42 (62.7) | 25 | 37 (58.7) | 26 | ||
| 3 = Poor | 38 (57.6) | 28 | 0.834 | 38 (64.4) | 21 | 0.725 |
| ER | ||||||
| Negative | 28 (51.9) | 26 | 35 (68.6) | 16 | ||
| Positive | 64 (68.1) | 30 | 0.050 | 46 (54.1) | 39 | 0.095 |
| PR | ||||||
| Negative | 39 (57.4) | 29 | 42 (66.7) | 21 | ||
| Positive | 53 (63.1) | 31 | 0.471 | 43 (56.6) | 33 | 0.225 |
| HER2 | ||||||
| Negative | 63 (58.3) | 45 | 58 (58.0) | 42 | ||
| Positive | 14 (63.6) | 8 | 0.645 | 14 (63.6) | 8 | 0.627 |
| Ki67 | ||||||
| Negative | 31 (48.4) | 33 | 36 (60.0) | 24 | ||
| Positive | 61 (67.8) | 29 | 0.016 | 51 (62.2) | 31 | 0.791 |
| Molecular subtype | ||||||
| Luminal A | 27 (52.9) | 24 | 27 (56.3) | 21 | ||
| Luminal B/HER2- | 24 (72.7) | 9 | 16 (53.3) | 14 | ||
| Luminal B/HER2+ | 5 (55.6) | 4 | 4 (44.4) | 5 | ||
| Basal-like TNBC | 15 (55.6) | 12 | 18 (75.0) | 6 | ||
| HER2-positive | 7 (77.8) | 2 | 0.091 | 8 (90.0) | 1 | 0.166 |
| CD44/CD24 status | ||||||
| CD44+/CD24- | 48 (57.8) | 35 | 47 (62.7) | 28 | ||
| Others | 40 (63.5) | 23 | 0.750 | 35 (60.3) | 23 | 0.792 |
Note: There are 1, 9, 15, 14, 35, 12 and 1 missing cases in Grade, pT stage, ER, PR, HER2, Ki67 and CD44/CD24 status, respectively. There are 132 cases could be classified on molecular subtype.
*
%represents rate of RRM2-High, which is equal to NHigh/(NHigh+NLow) × 100%.
‡
pT and pN stage are pathological stage.
In this study, no patient has > or = 4 lymph nodes involvement.
†
p values were based on Pearson Chi square test.