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Effects of MnTBAP on Aldo induced NLRP3 inflammasome activation in HK-2 cells. Cells were pretreated with MnTBAP (100 µM) for 30 min, followed by incubation with Aldo (100 nM) for 48 h. (A) Expressions of Nlrp3, pro-IL-1β, IL-1β, pro-IL-18, and IL-18 in HK-2 cells were quantified. Semi-quantitative analysis of Nlrp3 (B), IL-1β (C), and IL-18 (D) normalized against β-actin. Data represented as the mean ± SEM (n = 6). *P < 0.01 vs Control; #P < 0.01 versus Aldo-induced group.
