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NGF upregulates the serum level of VEGF and SDF-1 after ischemic stroke in rats. Blood samples were obtained from the abdominal aorta and the supernatant was collected. Serum levels of VEGF protein (A) or SDF-1 protein (B) in rats of the vehicle, NGF, and NGF + LY294002 groups on day 4 after MCAO, measured by ELISA. Rats from the NGF + LY294002 group showed significantly reduced VEGF expression compared to the NGF group. *P < 0.05 versus vehicle group, and #P < 0.05 versus NGF group.
