Table 1.
Non-collagenous biomolecules associated with RC tendon matrisome
| Biomolecules | Function | References |
|---|---|---|
| Small Leucine-Rich Proteoglycans (SLRPs) | Regulation of fibrillogenesis | [105] |
| Decorin | Mediator of fibrillogenesis by inhibiting fibril formation by lateral fusion, contribute to alignment, stability, strength and elasticity to collagen fibrils via surface interactions | [106] |
| Biglycan | Regulation of fibrillogenesis during development | [107] |
| Fibromodulin | Regulation of fibril fusion by inhibiting lateral fusion | [108] |
| Lumican | Regulation of fibril fusion | [109] |
| Cartilage oligomeric matrix protein (COMP) | Enhancer of collagen fibrillogenesis, mediates interaction between different components of ECM | [110] |
| Elastin | Stretch and recoil | [12] |
| Fibronectin | Cell adhesion | [111] |
| Laminins | Cell differentiation and migration | [112] |
| Tenascins | Load bearing and regeneration | [113] |
| Growth factors | Growth, repair and regeneration | [114] |
| MMPs | Repair and regeneration | [115] |