Table 3.
Role of growth factors in RCT
| Growth factor | Function | References |
|---|---|---|
| PDGF | Secretion of other GFs | [127] |
| Cell proliferation | ||
| Tendon healing | ||
| DNA synthesis | ||
| TGF-β | Tendon healing | [12] |
| Tendon matrix deposition | ||
| Scarring and fibrosis | ||
| VEGF | Endothelial cell proliferation | [128] |
| Angiogenesis | ||
| bFGF | Tendon cell migration and proliferation | [12] |
| Angiogenesis | ||
| Collagen type 1 gene expression | ||
| BMPs | Tenogenesis (BMP-12) | [129] |
| Tendon callus formation (BMP-13 & 14) | ||
| Mechanical strength | ||
| Tenoblast proliferation | ||
| Collagen type 1 and type 3 gene expression | ||
| IGF1 | Mechanical strength | [130] |