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. 2018 Dec 6;10:399. doi: 10.3389/fnagi.2018.00399

FIGURE 7.

FIGURE 7

Oral NAC supplementation prevents the spatial memory impairment caused by intra-hippocampal AβOs injections. Spatial memory of water deprived rats fed with NAC or vehicle for 21 days and injected intra-hippocampus with AβOs or saline was assessed in the Oasis maze task. (A) Quantification of hit rates for four groups of animals: injected with saline (white bars), with AβOs (black bars), NAC-fed and injected with AβOs (dark gray bars), and NAC-fed and injected with saline (light gray bars). The injections are indicated by arrows. (B) Quantification of the latency in each daily session for the four groups defined in A. (C) Distance ratios for the four experimental groups in each daily session. Values represent mean ± SE (n = 6). Statistical analysis was performed by two-way ANOVA, followed by Holm-Sidak post hoc test; ∗p < 0.05, ∗∗p < 0.01, and ∗∗∗p < 0.001 compared to control group; #p < 0.05, ##p < 0.01, and ###p < 0.001 compared to the AβOs-injected group.