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Schematic of the experimental design for the protocol of SuH-induced PAH. Echo Doppler images of the PA flow are showed for a normoxia and a SuH-induced PAH mice, with a mid-systolic notch being developed (red dashed line) in the PAH group at day 14 of protocol, as a sign of disease onset. SuH, SU5416/hypoxia; PA, pulmonary artery; PAH, pulmonary arterial hypertension.
