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. 2018 Dec 6;9:1395. doi: 10.3389/fphar.2018.01395

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Copyright © 2018 Alencar, Pimentel-Coelho, Montes, da Silva, Mendes, Montagnoli, Silva, Vasques, Rosado-de-Castro, Gutfilen, Cunha, Fraga, Silva, Martins, Ferreira, Mendes-Otero, Trachez, Sudo and Zapata-Sudo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of the treatment with vehicle or hMSC on heart structure and function of SuH-PAH mice. (A) Representative images of parasternal short-axis views obtained by B-mode echocardiography (all end-diastolic), (B) right ventricle area, (C) left ventricle area, and (D) right ventricular cardiac output 28 days after protocol initiation. (E) Left ventricle ejection fraction and (F) heart rate. Each column and bar represent the mean ± SEM (n = 5–7 mice per group). ^∗P < 0.05 compared with normoxia group; ^†P < 0.05 compared with SuH group treated with vehicle. Ordinary one-way ANOVA with multiple comparisons. hMSC, human mesenchymal stem-cell; SuH, SU5416/hypoxia; RV, right ventricle; LV, left ventricle.