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. 2018 Dec 6;9:1395. doi: 10.3389/fphar.2018.01395

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Copyright © 2018 Alencar, Pimentel-Coelho, Montes, da Silva, Mendes, Montagnoli, Silva, Vasques, Rosado-de-Castro, Gutfilen, Cunha, Fraga, Silva, Martins, Ferreira, Mendes-Otero, Trachez, Sudo and Zapata-Sudo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of SuH model on the cytokine levels measured by ELISA assessment in RVs from experimental groups. (A) Levels of TNF-α, (B) levels of IL-1β, and (C) levels of IL-6. Each column and bar represent the mean ± SEM (n = 3–7 mice per group). ^∗P < 0.05 compared with normoxia group; ^†P < 0.05 compared with SuH group treated with vehicle. Ordinary one-way ANOVA with multiple comparisons. hMSC, human mesenchymal stem-cell; SuH, SU5416/hypoxia; TNF-α, tumor necrosis factor alpha; IL-1β, interleukin-1 beta, IL-6, interleukin-6.