Table 2.
Patients who received a nonmyeloablative (with or without TBI) adoptive cell transfer with TCR
| Patient no. |
Cells | Prep | TBI (cGy) |
Age/ Sex |
Other disease sites | Cells (109) |
IL-2 dose |
Brain | Overall | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. | Size (mm) |
Res | Dur (mo) |
Res | Dur (mo) |
||||||||
| 1 | F4 | Cy/Flu | None | 32/F | SK | 4.7 | 5 | 1 | 5 | NR | NR | ||
| 2 | F5 | Cy/Flu | None | 46/M | AX, LU | 5.9 | 7 | 2 | 7 | CR | 25+ | PR | 25+ |
| 3 | F5 | Cy/Flu | None | 30/M | BO, AX, MT, LI, LU, PA, PV, HI | 112 | 8 | 1 | 5 | CR | 8 | NR | |
| 4 | F5 | Cy/Flu | None | 31/F | BR.SU | 73.7 | 8 | 1 | 2 | NR | NR | ||
| 5 | F5 | Cy/Flu | None | 43/F | IP, CE, CL, IL, IN, PE, SU, LU | 21.5 | 6 | 4 | 2 | NR | NR | ||
| 6 | gp100 | Cy/Flu | None | 25/F | ME, MS, LU, PL | 59.5 | 5 | 1 | 5 | NR | NR | ||
| 7 | gp154 | Cy/Flu | None | 40/F | MS, IL, MT, RP | 2.7 | 10 | 1 | 6 | NR | NR | ||
| 8 | gp154/F5 | Cy/Flu | 600 | 56/F | HI, ME, LU | 24.5 | 4 | 1 | 5 | NR | NR | ||
| 9 | gp154/F5 | Cy/Flu | 600 | 52/M | ME, EA, NK, SU, LU | 63.0 | 6 | 1 | 5 | NR | NR | ||
Abbreviations: Prep, preparative chemotherapy regimen; Dur, duration of response; mm, size of largest brain lesion in millimeters. AX, axilla; LI, liver; LU, lung; CL, clavicular; IL, iliac; RP, retroperitoneal; BR, breast; SU, subcutaneous; ME, mediastinal; SK, skin; AD, adrenal; SP, spleen; IN, inguinal; CE, cervical; MT, mesentery, PE, periaortic; KI, kidney; HI, hilar; SB, small bowel; BO, bone; PP, periportal; IP, intraperitoneal; MS, muscle; EA, ear; EY, eye; PL, pleura; PV, pelvis; PA, pancreas; NK, neck; Cy, cyclophosphamide; Flu, fludarabine.