Table 1.

Summary of CCp/LAP expression and phenotype in Plasmodium

	P. berghei/P. yoelii			P. falciparum
	Accession no.	Subcellular localization	Function or KO phenotype	Subcellular localization	Function or KO phenotype
CryPH	PBANKA_0704900	Crystalloid body	CryPH is dispensable for ookinete, oocyst, sporozoite formation	ND	ND
PfCCp1/PbLAP2	PBANKA_1300700	Gametocyte cytoplasm and crystalloid body in ookinetes [26]	LAP2 knockout parasites form oocysts in the normal number, but fail to produce sporozoites inside [35]	Female gametocyte surface (punctate pattern) [31]
PfCCp2/PbLAP4	PBANKA_1319500	Crystalloid body in developing ookinetes [27]	LAP4 is essential for oocyst maturation and sporozoite formation [35]	Female gametocyte surface (punctate pattern) [31]	In CCp2 deficient parasites, oocyst formation is normal but sporozoites were unable to invade salivary glands [29]
PfCCp3/PbLAP1 (PbSR)	PBANKA_1035200	Crystalloid body in developing ookinetes [14]	PbSR is involved in crystalloid formation. It is dispensable for the oocyst formation but essential for sporozoite formation inside [14, 33]	Female gametocyte surface (punctate pattern) [31]	CCp3 deficient mutant lacks CCp1 and CCp2. Sporozoites form normally in oocysts, however they lost abilities of release into hemocoel and invasion of salivary glands [29]
PfCCp4/PbLAP6	PBANKA_0417600	Crystalloid body in developing ookinetes [27]	LAP6 is essential for oocyst maturation and sporozoite formation [35]	Female gametocyte surface (homogenous expression) [31] Co-localized with Pfs230	CCp4 is dispensable for parasite development in the mosquito vector [31]
PfCCp5/PbLAP3	PBANKA_0204500	Gametocyte cytoplasm and crystalloid body in ookinetes [26]	LAP3 is essential for crystalloid body formation, and for oocyst maturation to produce sporozoites [67]	Female gametocytes (at the pole) [31]
PfFNPA/PbLAP5	PBANKA_1315300	Crystalloid body in developing ookinetes [27]	LAP5 knockout parasites form oocysts in the normal number, but fail to produce sporozoites inside [36]	Female gametocytes (at the pole) [31]

Carter et al. [14], Saeed et al. [26, 27], Pradel et al. [29], Scholz et al. [31], Claudianos et al. [33], Raine et al. [35], Ecker et al. [36], Saeed et al. [67] 2015

ND not done