Table 2.
Intrinsic functional connectivity of fronto-subcortical pairs for children with attention-deficit hyperactivity disorder (ADHD) and typically developing (TD) controls
| TD | ADHD | Group differences | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Girls (n = 21) |
Boys (n = 54) |
All (n = 75) |
Girls (n = 20) |
Boys (n = 52) |
All (n = 72) |
Dx | Dx × Sex | All | Girls | Boys | |||||||
| Mean | SD | Mean | SD | Mean | SD | Mean | SD | Mean | SD | Mean | SD | p | p | d | d | d | |
| F1-S1 | 0.26 | 0.15 | 0.25 | 0.15 | 0.25 | 0.16 | 0.36 | 0.15 | 0.29 | 0.15 | 0.32 | 0.17 | .012a | .291 | 0.42a | 0.66b | 0.27 |
| F2-S1 | 0.65 | 0.15 | 0.68 | 0.15 | 0.66 | 0.16 | 0.74 | 0.15 | 0.68 | 0.14 | 0.71 | 0.16 | .092 | .079 | 0.28 | 0.64b | 0.01 |
| F3-S1 | − 0.45 | 0.16 | − 0.52 | 0.16 | − 0.49 | 0.18 | − 0.57 | 0.16 | − 0.53 | 0.16 | − 0.55 | 0.18 | .041b | .048b | 0.33b | 0.74b | 0.01 |
| F1-S2 | − 0.31 | 0.16 | − 0.28 | 0.15 | − 0.29 | 0.17 | − 0.16 | 0.15 | − 0.25 | 0.15 | − 0.20 | 0.17 | .002a | .042b | 0.51a | 0.94a | 0.20 |
| F2-S2 | 0.02 | 0.15 | 0.06 | 0.15 | 0.04 | 0.16 | 0.09 | 0.15 | 0.06 | 0.14 | 0.07 | 0.16 | .183 | .172 | 0.22 | 0.49 | 0.01 |
| F3-S2 | − 0.39 | 0.15 | − 0.41 | 0.15 | − 0.40 | 0.16 | − 0.42 | 0.15 | − 0.39 | 0.15 | − 0.41 | 0.16 | .805 | .310 | 0.04 | 0.23 | 0.14 |
Estimated marginal mean (SD) functional connectivity values for the ADHD and TD groups. F1 frontal component 1 (ventromedial PFC), F2 frontal component 2 (medial PFC/anterior cingulate cortex), F3 frontal component 3 (anterior dorsolateral PFC), S1 subcortical component 1 (striatum), S2 subcortical component 2 (amygdala/hippocampus). Cohen’s d is reported as an estimate of effect size. Uncorrected p values are reported. aSignificant effect after FDR correction applied for six tests; bSignificant effect without FDR correction