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. 2018 Dec 12;37:308. doi: 10.1186/s13046-018-0974-1

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Elevated GRINA expression in gastric cancer. a Heatmap of 36 dysregulated genes on chromosome 8q24 (fold change > 1.5 or fold < − 1.5; q value < 0.001). Each column represents an individual sample and each row represents one gene. b Relative GRINA mRNA expression in 415 gastric cancer samples and 35 normal samples from TCGA database. c Relative GRINA mRNA expression in 32 gastric cancer samples and 32 matched normal samples from TCGA database. d Relative GRINA mRNA expression in 38 gastric cancer samples and 31 normal samples from GSE13911 database. e-f mRNA and protein levels of GRINA in 20 pairs of fresh gastric cancer samples were determined by real-time PCR and western blotting. T, tumor sample; N, normal sample. (N = 3). Values are mean ± s.d., ***P < 0.001 (Student’s t-test)