Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Dec 12;37:308. doi: 10.1186/s13046-018-0974-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Fig. 6 — GRINA facilitated gastric cancer cell survival by modulating aerobic glycolysis. a GSEA plot based on the gene expression profiles of gastric cancer samples from TCGA database. b-c Relative mRNA levels of glycolysis-related genes in the control groups and the shRNA groups (N = 3). d-e Relative mRNA levels of glycolysis-related genes in the control groups and the GRINA-OE groups (N = 3). f-g Extracellular acid ratio (ECAR) upon knockdown of GRINA or not in BGC-823 and AGS cells. Glc, glucose; O, oligomycin; 2-DG, 2-deoxyglucose (N = 3). (H-I) ECAR upon overexpression of GRINA or not in HGC27 and N87 cells. Glc, glucose; O, oligomycin; 2-DG, 2-deoxyglucose (N = 3). j After GRINA expression was downregulated, total and phosphorylated Akt, P70S6K, 4EBP1 were measured by western blotting analysis (N = 3). Values are mean ± s.d., *P < 0.05, **P < 0.01, ***P < 0.001 (Student’s t-test)