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. 2018 Dec 12;37:308. doi: 10.1186/s13046-018-0974-1

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — GRINA knockdown promoted cell apoptosis via Bcl-2 family members. a-b Cell apoptosis assay revealed that apoptosis rates of BGC-823 and AGS cells increased when GRINA was silenced (N = 3). c TUNEL staining reaveled that mice tumor tissues in the GRINA-shRNA group showed higher apoptosis rate than those in the control group (N = 3). d Bcl-2, Bax, Cleaved-caspase3, Cleaved-caspase7, Cleaved-caspase9 were measured by western blotting analysis after GRINA was silenced in BGC-823 and AGS cell lines (N = 3). Values are mean ± s.d., *P < 0.05, ***P < 0.001 (Student’s t-test)