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a Under normal condition (absence of METH), there are reciprocal interactions occurring between DA neurons and microglia. b METH-mediated dysregulation of DA neurons alters neuronal-microglial interactions leading to mild microglial activation; however, the intercellular signaling is unknown. c It is unknown whether or not METH can directly induce microglial activation or otherwise alter microglial function to influence its neurotoxicity
