Fig. 3.

Distribution of $R_{\mathit{\text{pred}}}^2$ values. Box plot illustrating the distribution of $R_{\mathit{\text{pred}}}^2$ values from the analysis of TCGA pan cancer data using the MSigDB curated canonical pathways (C2.CP) collection. Values are shown for three different analyses: COSMIC: estimation of pathway regression models using somatic alteration data for COSMIC consensus cancer genes, All TCGA: estimation of models using somatic alteration data for all genes included in the TCGA datasets, and Random: estimation of models using randomized somatic alteration data for COSMIC consensus cancer genes