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. 2018 Dec 12;19:479. doi: 10.1186/s12859-018-2476-8

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© The Author(s) 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Enrichment of known cancer driver genes. The false discovery rate (FDR) q-values (as computed using the Benjamini and Hochberg (BH) [38] method) for the Wilcox rank sum tests of enrichment of known driver genes among the ranks of all predictors for the MSigDB C2.CP models using all TCGA genes. The q-value for each cancer type cohort is plotted relative to the cohort sample size. All but one cancer type has a q-value of < 0.1 with a general association between significance and sample size