Table 5.

Linear regression (univariate & multivariate) models show associations of averaged yearly NfL with year 1 and year 10 T25FW difference

	Univariate					Multivariate
Variable	N	Estimate	95% CI	P‐value	Correctiona	N	Estimate	95% CI	P‐value	Correctiona	R² Full	R² Reduced
Average year 1–2 NfL	80	−0.077	−0.034,0.019	0.5691	1.0000	80	−0.115	−0.039,0.016	0.4123	1.0000	0.053	0.044
Average year 1–3 NfL	89	−0.135	−0.051,0.024	0.4734	1.0000	89	−0.194	−0.058,0.019	0.3221	1.0000	0.051	0.039
Average year 1–4 NfL	92	−0.188	−0.064,0.026	0.4061	1.0000	92	−0.258	−0.072,0.021	0.2749	1.0000	0.052	0.039
Average year 1–5 NfL	92	−0.165	−0.055,0.022	0.3979	1.0000	92	−0.260	−0.067,0.015	0.2085	1.0000	0.056	0.039
Average year 1–6 NfL	92	−0.169	−0.061,0.027	0.4455	1.0000	92	−0.283	−0.075,0.018	0.2267	1.0000	0.055	0.039
Average year 1–7 NfL	92	−0.208	−0.069,0.028	0.3974	1.0000	92	−0.322	−0.083,0.019	0.2113	1.0000	0.056	0.039
Average year 1–8 NfL	92	−0.219	−0.075,0.031	0.4112	1.0000	92	−0.336	−0.088,0.021	0.2251	1.0000	0.055	0.039
Average year 1–9 NfL	92	−0.186	−0.068,0.031	0.4597	1.0000	92	−0.291	−0.081,0.022	0.2647	1.0000	0.052	0.039
Average year 1–10 NfL	92	−0.172	−0.067,0.033	0.4954	1.0000	92	−0.277	−0.079,0.024	0.2875	1.0000	0.051	0.039
Average year 2–10 NfL	92	−0.161	−0.067,0.035	0.5327	1.0000	92	−0.253	−0.077,0.027	0.3371	1.0000	0.049	0.039
Average year 3–10 NfL	92	−0.145	−0.064,0.035	0.5647	1.0000	92	−0.234	−0.074,0.028	0.3629	1.0000	0.048	0.039
Average year 4–10 NfL	92	−0.145	−0.064,0.035	0.5586	1.0000	92	−0.234	−0.074,0.027	0.3563	1.0000	0.048	0.039
Average year 5–10 NfL	92	−0.108	−0.055,0.034	0.6312	1.0000	92	−0.193	−0.065,0.026	0.4017	1.0000	0.046	0.039
Average year 6–10 NfL	92	−0.092	−0.060,0.042	0.7204	1.0000	92	−0.154	−0.067,0.036	0.5541	1.0000	0.042	0.039
Average year 7–10 NfL	92	−0.107	−0.055,0.034	0.6343	1.0000	92	−0.147	−0.059,0.030	0.5141	1.0000	0.043	0.039
Average year 8–10 NfL	92	−0.071	−0.052,0.038	0.7531	1.0000	92	−0.151	−0.061,0.030	0.5114	1.0000	0.043	0.039
Average year 9–10 NfL	85	−0.036	−0.024,0.017	0.7313	1.0000	85	−0.049	−0.026,0.016	0.6466	1.0000	0.008	0.006
Average year 5–6 NfL	92	−0.072	−0.040,0.026	0.6638	1.0000	92	−0.158	−0.050,0.019	0.3656	1.0000	0.048	0.039
Average year 5–7 NfL	92	−0.134	−0.055,0.028	0.5202	1.0000	92	−0.218	−0.064,0.021	0.3102	1.0000	0.050	0.039
Average year 5–8 NfL	92	−0.149	−0.062,0.032	0.5285	1.0000	92	−0.241	−0.072,0.024	0.3187	1.0000	0.050	0.039
Average year 5–9 NfL	92	−0.126	−0.058,0.033	0.5801	1.0000	92	−0.212	−0.067,0.025	0.3619	1.0000	0.048	0.039

The estimate corresponds to the change in the mean of the outcome for a 10 pg/mL increase in NfL.

^aAdjusted for multiple comparisons using Bonferroni correction.