Table 6.

Linear regression (univariate & multivariate) models show associations of averaged yearly NfL with BPF

	Univariate					Multivariate
Variable	N	Estimate	95% CI	P‐value	Correctiona	N	Estimate	95% CI	P‐value	Correctiona	R² Full	R² Reduced
Average year 1–2 NfL	81	−0.422	−0.068,−0.017	0.0014	0.0291	81	−0.440	−0.070,−0.018	0.0013	0.0280	0.164	0.041
Average year 1–3 NfL	89	−0.645	−0.103,−0.026	0.0012	0.0262	89	−0.683	−0.108,−0.028	0.0011	0.0227	0.156	0.041
Average year 1–4 NfL	91	−0.776	−0.126,−0.029	0.0021	0.0447	91	−0.823	−0.133,−0.032	0.0017	0.0355	0.150	0.046
Average year 1–5 NfL	91	−0.849	−0.128,−0.042	0.0002	0.0035	91	−0.920	−0.137,−0.046	0.0001	0.0027	0.197	0.046
Average year 1–6 NfL	91	−0.922	−0.142,−0.043	0.0004	0.0081	91	−0.985	−0.151,−0.046	0.0004	0.0079	0.177	0.046
Average year 1–7 NfL	91	−0.985	−0.155,−0.041	0.0009	0.0192	91	−1.058	−0.167,−0.045	0.0009	0.0179	0.162	0.046
Average year 1–8 NfL	91	−1.019	−0.165,−0.039	0.0019	0.0402	91	−1.064	−0.174,−0.039	0.0023	0.0478	0.144	0.046
Average year 1–9 NfL	91	−0.972	−0.158,−0.037	0.0020	0.0413	91	−1.004	−0.165,−0.036	0.0026	0.0540	0.142	0.046
Average year 1–10 NfL	91	−0.907	−0.152,−0.029	0.0045	0.0938	91	−0.911	−0.156,−0.026	0.0069	0.1446	0.124	0.046
Average year 2–10 NfL	91	−0.777	−0.145,−0.011	0.0234	0.4911	91	−0.738	−0.144,−0.003	0.0399	0.8378	0.092	0.046
Average year 3–10 NfL	91	−0.673	−0.133,−0.002	0.0442	0.9275	91	−0.624	−0.131,0.006	0.0740	1.0000	0.081	0.046
Average year 4–10 NfL	91	−0.627	−0.128,0.003	0.0611	1.0000	91	−0.560	−0.124,0.012	0.1075	1.0000	0.074	0.046
Average year 5–10 NfL	91	−0.568	−0.116,0.003	0.0605	1.0000	91	−0.496	−0.112,0.012	0.1153	1.0000	0.073	0.046
Average year 6–10 NfL	91	−0.183	−0.095,0.059	0.6368	1.0000	91	−0.054	−0.084,0.073	0.8910	1.0000	0.046	0.046
Average year 7–10 NfL	91	−0.183	−0.090,0.054	0.6151	1.0000	91	−0.060	−0.079,0.067	0.8707	1.0000	0.046	0.046
Average year 8–10 NfL	91	−0.331	−0.093,0.027	0.2775	1.0000	91	−0.213	−0.083,0.040	0.4949	1.0000	0.051	0.046
Average year 9–10 NfL	86	−0.350	−0.072,0.002	0.0659	1.0000	86	−0.303	−0.069,0.008	0.1196	1.0000	0.074	0.046
Average year 5–6 NfL	90	−0.564	−0.096,−0.017	0.0057	0.1188	90	−0.561	−0.098,−0.014	0.0093	0.1952	0.120	0.047
Average year 5–7 NfL	91	−0.614	−0.115,−0.008	0.0253	0.5323	91	−0.613	−0.118,−0.004	0.0354	0.7442	0.094	0.046
Average year 5–8 NfL	91	−0.630	−0.127,0.001	0.0524	1.0000	91	−0.582	−0.125,0.009	0.0886	1.0000	0.078	0.046
Average year 5–9 NfL	91	−0.651	−0.125,−0.005	0.0327	0.6865	91	−0.600	−0.123,0.003	0.0607	1.0000	0.084	0.046

The estimate corresponds to the change in the mean of the outcome for a 10 pg/mL increase in NfL.

^aAdjusted for multiple comparisons using Bonferroni correction.