Fig 3.

Modified cortisol profiles after dosing of synthetic glucocorticoids (GC) by bolus injection at the nominal amount (1×). The modified cortisol rhythm is indicated by the blue line. The black line corresponds to the nominal cortisol profile based on endogenous HPA axis activity. The pharmacokinetic profiles for the bolus injection are indicated by the dotted green line. The grey shaded areas represent the time at which the system is not exposed to light. Cortisol concentration is given in arbitrary units (a.u.).