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. Author manuscript; available in PMC: 2019 Nov 1.
Published in final edited form as: Chronobiol Int. 2018 Jul 30;35(12):1619–1636. doi: 10.1080/07420528.2018.1498098

Fig 5.

Fig 5.

Relationship between the relative amplitude and phase difference of the modified cortisol rhythm after long-term once-daily chronopharmacological dosing of synthetic glucocorticoids. Amplitude and phase for the modified cortisol rhythms after chronic administration of a daily bolus injection and the slow-acting oral dose are shown in A and B, respectively. Marker labels correspond to the time of administration. Marker color indicates the administration time relative to the nominal cortisol rhythm where blue circles correspond to dosing times from 8:00 PM to 6:00 AM (ascending phase of baseline rhythm), red squares correspond to dosing times from 7:00 AM to 8:00 AM (near peak of baseline rhythm), green diamonds correspond to dosing times from 9:00 AM to 5:00 PM (descending phase of baseline rhythm), and yellow triangles correspond to dosing times from 6:00 PM to 7:00 PM (near nadir of baseline rhythm).