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. Author manuscript; available in PMC: 2019 Nov 1.
Published in final edited form as: Chronobiol Int. 2018 Jul 30;35(12):1619–1636. doi: 10.1080/07420528.2018.1498098

Fig 6.

Fig 6.

Amplitude of the modified cortisol rhythm after single and repeated once-daily chronopharmacological dosing of synthetic glucocorticoids by bolus injection at the nominal dose. The relative amplitude associated with the modified cortisol rhythm after a single injection and after long-term once-daily IV dosing are shown. The relative change in amplitude is calculated by Relative Amplitude (%) = [(Amptreatment − Ampbaseline)/Ampbaseline] × 100%. Cortisol concentration is given in arbitrary units (a.u.).