Fig. 7:

Influence of chronic once-daily chronopharmacological dosing on the total cortisol exposure. The relationship between the 24-hour AUC and amplitude change after long-term dosing of a daily bolus injection at the nominal dose (1×) is shown in A. The modified cortisol profiles after dosing and for the baseline conditions are given in B for selected dosing times. The grey shaded areas represent the simulated night, that is the time at which the system is not exposed to light. Cortisol concentration is given in arbitrary units (a.u.).