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. 2018 Dec 5;9:611. doi: 10.3389/fgene.2018.00611

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Copyright © 2018 Chen, Liu, Chen, Chen, Shen, Liu, Li, Li, Lin, Yang, Ni, Zhou, Zhang, Tian, Li and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Reverse transcription-quantitative polymerase chain analysis confirmed the efficiency of transfected (A) Eca109 or (B) Eca109R cells with si-FAM201A and FAM201A-mimic. In both (C) Eca109 or (D) Eca109R cancer cells transfected with si-FAM201A or FAM201A-mimic, the percentage of apoptotic cells in each line increased with the increasing X-ray irradiation dose. In contrast to the levels of apoptosis, cell proliferation decreased with increasing radiation doses in (E) Eca109 or (F) Eca109R. The effect of shFAM201A on Xenograft tumor survival was also evaluated: (G) tumor survival curve, (H) tumor volume and weight. **P < 0.01, ***P < 0.001.