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. 2017 Nov;95(11):4945–4957. doi: 10.2527/jas2017.1837

Table 5.

Metabolic, humoral, and gene expression responses in beef steers supplemented or not (no immunomodulatory ingredient supplementation during feedlot receiving [CON]; n = 6) with immunostimulant ingredients (IPF1 [n = 6] and OMN2 [n = 6]) from d 0 to 30 of the receiving period3,4

Item CON IPF OMN SEM P-value
Metabolic variables
    Plasma cortisol, ng/mL 21.89a 18.74b 18.63b 0.92 0.02
    Plasma IGF-I, ng/mL 178 166 175 7 0.41
Serum antibody variables, titer log 2
    Mannheimia haemolytica 10.44 10.41 10.23 0.23 0.79
    Parainfluenza-3 virus 6.65 5.99 6.18 0.51 0.66
    Bovine respiratory syncytial virus 5.59 5.47 4.81 0.43 0.39
    Bovine viral diarrhea virus-1 5.77 6.19 6.16 0.51 0.81
    Bovine herpesvirus-1 3.53 3.02 4.15 0.43 0.21
Blood mRNA expression
    Chemokine ligand 5 4.47 3.22 2.89 0.61 0.24
    Cyclooxygenase 2 3.93 3.34 3.88 0.53 0.69
    Interleukin 8 receptor 4.86 4.73 5.44 0.97 0.85
    L-selectin 1.83 1.78 1.75 0.12 0.91
a,b

Values within rows with different superscripts differ (P ≤ 0.05).

1

IPF = 2 oral capsules of Stocker Immune Primer on d 0 + 15 g/steer daily (as-fed basis) of Stocker Preconditioned Premix (Ramaekers Nutrition, Santa Cruz, CA) from d 7 to 30.

2

OMN = supplementation with OmniGen-AF (22 g/steer daily, as-fed basis, from d 0 to 30; Phibro Animal Health Corp., Teaneck, NJ).

3

On d 0, steers were vaccinated against Clostridium and Mannheimia haemolytica (One Shot Ultra 7; Zoetis Inc., Florham Park, NJ) and infectious bovine rhinotracheitis, bovine viral diarrhea complex, parainfluenza-3 virus, and bovine respiratory syncytial virus (Bovi-Shield Gold 5; Zoetis Inc.) and were administered an anthelmintic (Dectomax; Zoetis Inc.). On d 21, steers were revaccinated against Clostridium (Ultrabac 8; Zoetis Inc.) and infectious bovine rhinotracheitis virus, bovine viral diarrhea complex, parainfluenza-3 virus, and bovine respiratory syncytial virus (Bovi-Shield Gold 5; Zoetis Inc.).

4

Blood samples were collected on d 0, 3, 7, 10, 14, 21, 31, 42, and 73 and analyzed for cortisol (d 0 to 31), IGF-I (d 0, 21, 42, and 73), serum antibody variables (d 0, 10, 21, 31, and 42), and whole-blood mRNA expression (d 0 to 14).