Table 1.
NTM | Calcium level | Normal reference range | Timeframe between trigger and hypercalcemia | Trigger for hypercalcemia | [1,25](OH)2 D3 | |
---|---|---|---|---|---|---|
Delahunt et al.[10] | Mycobacterium avium | 11.8 | 8.5–10.2 | Initial presentation | NTM treatment | ↑ |
Lin et al.[11] | Mycobacterium haemophilum | 19.6 | 8.5–10.2 | Initial presentation | No identified trigger | ↑ |
Playford et al.[17] Two cases |
Mycobacterium avium | 14.6 13.2 |
8.5–10.2 | 4 months 4 weeks | NTM therapy NTN therapy | N ↑ |
Aly et al.[37] | Mycobacterium avium | 13.3 | 8.5–10.2 | Not available | Not available | N |
Newell et al.[38] | Mycobacterium avium intracellulare | 10.8 | 8.5–10.2 | 2 weeks | ART | . |
Nielsen et al.[19] | Mycobacterium marinum | 7.12 (ionized calcium) |
4.6–5.2 | 4 weeks | NTM therapy | ↓ |
Shrayyef et al.[7] | Mycobacterium avium intracellulare | 13.7 | 8.5–10.2 | 3 weeks | Vitamin D therapy | N |
Ayoubieh et al.[18] | Mycobacterium avium intracellulare | 12 | 8.5–10.2 | 4 weeks | Discontinuation of NTM therapy | ↓ |
Parsons et al.[9] | Mycobacterium avium complex | 12.8 | 8.5–10.2 | Initial presentation | No identified trigger | N |
↑, increased; N, normal; .(period), no data; ↓, decreased.