Table 2.
Summary of the diagnostic accuracy of OPN, AFP, and OPN+AFP
| Marker | Pooled sensitivity | Pooled specificity | PLR | NLR | DOR | AUC |
|---|---|---|---|---|---|---|
|
| ||||||
| OPN | 0.813 (0.671–0.902) | 0.874 (0.778–0.932) | 6.436 (3.299–12.553) | 0.214 (0.111–0.413) | 30.047 (8.845–102.067) | 0.91 (0.89–0.94) |
| AFP | 0.639 (0.538–0.729) | 0.959 (0.909–0.982) | 15.618 (6.384–38.209) | 0.376 (0.283–0.501) | 41.518 (13.688–125.929) | 0.88 (0.85–0.90) |
| OPN+AFP | 0.856 (0.760–0.918) | 0.738 (0.630–0.823) | 3.266 (2.257–4.727) | 0.195 (0.115–0.333) | 16.718 (7.950–35.156) | 0.85 (0.82–0.88) |
Abbreviations: AFP, alpha-fetoprotein; AUC, area under curve; DOR, diagnostic odds ratio; NLR, negative likelihood ratio; OPN, osteopontin; PLR, positive likelihood ratio.