Table 1. Comparison of the inhibition activity of various PARP inhibitors between PARP1 and bacterially expressed GST-TIPARP.

Inhibitor	IC50 (M)
	PARP1	TIPARP
3ABA	1.7 ± 0.4 × 10−4*	9.8 ± 4.0 × 10−4
PJ34	5.5 ± 1.4 × 10−8*	2.6 ± 1.1 × 10−5
Olaparib	1.4 ± 0.04 × 10−7*	8.0 ± 2.0 × 10−7
KU0058948	7.6 ± 0.4 × 10−8	n.d.

Abbreviations: n.d., not determined because greater than 50% inhibition was not achieved.

^*Significantly different compared with treatment matched TIPARP.