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. 2018 Nov 21;564(7734):64–70. doi: 10.1038/s41586-018-0734-6

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© Springer Nature Limited 2018

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Fig. 2 — a, Percentage of methylated CpG dinucleotides in oyster (mantle, n = 14,779,123), amphioxus (8 hpf, n = 19,657,388) and zebrafish (1,000-cell stage, n = 38,989,847) samples. Low, >0–20%; medium, 20–80%; high, >80%. b, k-means clustering (n = 2) of 5mC signal over hepatic-specific APREs. c, Percentage of methylated CpG dinucleotides as assessed by whole-genome bisulfite sequencing (WGBS) and reduced representation bisulfite sequencing (RRBS) in embryos and adult tissues in APREs from b. d, Distribution of expression levels for genes associated with APREs displaying distinct 5mC patterns in b. Cluster 1: 1,114 genes; cluster 2: 1,594 genes. cRPKM, corrected (per mappability) reads per kb of mappable positions and million reads. Hep, hepatic diverticulum. e, Genomic distribution of regions with distinct 5mC patterns from b. Hep. dyn., dynamic APREs active in the hepatic diverticulum.