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. Author manuscript; available in PMC: 2019 Apr 12.
Published in final edited form as: Science. 2018 Oct 12;362(6411):181–185. doi: 10.1126/science.aat0473

Figure 1. Origin and overview of CNS glial cells.

Figure 1.

A: Radial Glial Cell in an E14 mouse cortex, visualised following in utero electroporation of GFP (green), and co-­stained for apical centrosomes (pericentrin, red) and cell nuclei (DAPI, blue). Image courtesy of Sven Falk and Magdalena Goetz, Helmholtz Centre, Munich.

B: Radial glial cells are the principal neuroepithelial progenitor cells of the central nervous system, and generate the majority of CNS neurons and glia, either directly (e.g. neurons), or indirectly through intermediate progenitors (e.g. OPCs). Microglia (yellow) enter the CNS during embryonic development.

C: Neurons and glia interact in a myriad of ways (indicated by circles, explained in text and subsequent figures).